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KMID : 0359319970370030595
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Korean Journal of Veterinary Research
1997 Volume.37 No. 3 p.595 ~ p.599
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Efficacy of closantel against Fasciola hepatica in experimentally-infected rats
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Kim Jong-Taek
Lee Chung-Gil
Cho Shin-Hyeong
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Abstract
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Male and female Sprague-Dawley rats 8 weeks of age were inoculated per os with 10 Fasciola hepatica metacercariae each. After the infection was verified by fecal examination, they were divided into four groups at 14 weeks post-inoculation; three groups were dosed orally at 10, 20 and 30mg/kg of closantel(Flukiver TM), a salicylanilide compound and the rest used as untreated control. Efficacy of closantel was monitored weekly by fecal examination of all infected animals starting during the second week post-treatment(PT) and continuing for three weeks. Closantel elicited 96.0, 86.9 and 87.4% efficacy in rats treated with 10mg/kg at the second, third and fourth week PT, respectively. It elicited a 100% efficacy in rats treated with 20 and 30mg/kg.
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KEYWORD
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Fasciola hepatica , rat , closantel , egg counts
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